This website uses cookies to ensure you get the best experience on our website. More info

Publications

Please find our recommended publications involving Inflazome
founders and general inflammasome information.


General Inflammasome Information

Taming the inflammasome

Read More

Inflammasome inhibition: 
putting out the fire

Read More


Publications

Inflammasome inhibition prevents a-synuclein pathology and dopaminergic neurodegeneration in mice

Gordon et al
Science Translational Medicine, (2018)

The NLRP3 Inflammasome Suppresses Protective Immunity to Gastrointestinal Helminth Infection

Alhallaf et al
Cell Reports, (2018)

Multiple inflammasomes may regulate the interleukin-1-driven inflammation in protracted bacterial bronchitis

Chen et al
ERJ Open Research, (2018)

Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950

Salla et al
Bioorganic & Medicinal Chemistry Letters, (2018)

Pharmacological inhibition of the NLRP3 inflammasome as a potential treatment for multiple sclerosis induced central neuropathic pain

Khan et al
Inflammopharmacology, (2017)

Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome

Sano et al
Journal of the American College of Cardiology, (2018)

Evidence against a role for NLRP3-driven islet inflammation in db/db mice

Kammoun et al
Molecular Metabolism, (2018)

CD8+ lineage dendritic cells determine adaptive immune responses to inflammasome activation upon sterile skin injury

Chakraborty et al
Experimental Dermatology, (2018)

Blocking the NLRP3 inflammasome activation directly with a small molecule could be safer than biologic therapies targeting IL-1beta

O'Neill et al
New England Journal of Medicine, (2018)

An optimized whole blood assay measuring expression and activity of NLRP3, NLRC4 and AIM2 inflammasomes

Grinstein et al
Clinical Immunology, (2017)

Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress

Dinh et al
Aging, (2017)

NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction

Pavillard et al
Oncotarget, (2017)

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice

Dempsey et al
Brain, Behaviour and Immunity, (2017)

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation

Chen et al
Nature Microbiology, (2017)

High fat diet-induced obesity promotes steroid-resistant asthma through an NLRP3 inflammasome-dependent mechanism

Pinkerton
Respirology, (2017)

PB1-F2 peptide derived from avian influenza A virus H7N9 induces inflammation via activation of the NLRP3 inflammasome

Pinar et al
The Journal of Biological Chemistry, (2017)

NLRP3 inflammasome-mediated, IL-1β-dependent inflammatory responses drive steroid-resistant asthma

Kim et al
American Journal of Respiratory and Critical Care Medicine, (2017)

Lipocalin-2 induces NLRP3 inflammasome activation via HMGB1 induced TLR4 signaling in heart tissue of mice under pressure overload challenge

Song et al
American Journal of Translational Research, (2017)

Myeloid-derived miR-223 regulates intestinal in ammation via repression of the NLRP3 inflammasome

Neudecker et al
The Journal of Experimental Medicine, (2017)

Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation

Chen et al
Nature Microbiology, (2017)

Sulfonylureas as Concomitant Insulin Secretagogues and NLRP3 Inflammasome Inhibitors

Hill et al
ChemMedChem, (2017)

Role for NLRP3 inflammasome-mediated, IL-1β-dependent responses in severe, steroid-resistant asthma

Kim et al publications: American Journal of Respiratory and Critical Care Medicine, (2017)

Inflammasomes in the lung

Pinkerton et al
Molecular Immunology, (2017)

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

Mridha et al
Journal of Hepatology, (2017)

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

Fuster et al
Science, (2017)

Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-b and cognitive function in APP/PS1 mice

Dempsey et al
Brain, Behavior, and Immunity, (2017)

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

Basiorka et al
BLOOD, (2016)

Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950

Salla et al
ACS Medicinal Chemistry Letters, (2016)

IL-1β is an innate immune sensor of microbial proteolysis

LaRock et al
Science Immunology, (2016)

The Endoplasmic Reticulum-Mitochondrion Tether ERMES Orchestrates Fungal Immune Evasion, Illuminating Inflammasome Responses to Hyphal Signal

Tucey et al
mSphere, (2016)

NLRP3 inflammasome-mediated, IL-1β-dependent inflammatory responses drive steroid-resistant asthma

Horvat et al
European Respiratory Journal, (2016)

K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

Groß et al
Immunity, (2016)

Role of the NLRP3 inflammasome in a model of acute burn-induced pain

Deuis et al
BURNS, (2016)

Identification, synthesis and biological evaluation of the major human metabolite of NLRP3 inflammasome MCC950

Salla et al
ACS Medicinal Chemistry Letters, (2016)

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

Arbore el al
Science, (2016)

Human Monocytes Engage an Alternative Inflammasome Pathway

Gaidt et al
Immunity (2016)

The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction

Van Hout et la
European Heart Journal, (2016)

Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition

Tate et al
Scientific Reports, (2016)

A small molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Coll et al
Nature Medicine, (2015)

Inflammasomes in COPD and neutrophilic asthma

Kim et al
Thorax, (2015)

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5

Baker et al
European Journal of Immunology, (2015)

Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice

Krishnan et al
British J. Pharmacol., (2015)

Strain- and host species-specific inflammasome activation, IL-1β release, and cell death in macrophages infected with uropathogenic Escherichia coli

Scaale et al
Mucosal Immunology, (2015)

Follow our Progress & Insights

Inflazome is making rapid progress in advancing our clinical and preclinical assets. Keep up with the latest news on Inflazome’s research and development activities with regular email updates.

Speak to us about
a better tomorrow

Contact Us

×